Roche Diagnostics Operations, Inc.

Ventana Medical Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Daniel Mueller

Emad Sarofim

Goran Savatic

Oliver Gutmann

Claudio Cherubini

Andreas Drechsler

Martin Kopp

Chris Steinert

Reto Huesser

Raymond T Kozikowski, Iii

Nenad Milicevic

Melis Hazar

Edwin Oosterbroek

Michael Glauser

Michael Zeder

Geza Burghardt

Roger Sandoz

Uta Schaffner

Raymond Kozikowski

A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (), comprising at least one microfluidic reagent applicator (); at least one bulk fluid applicator (); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system () that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.

Systems and methods for staining of biological samples

A method for unsealing an opening of a laboratory sample container containing a sample is presented. The opening is sealed by a closure attached to the laboratory sample container by an adhesive. An adhesive strength of the adhesive is lowerable by treatment. The method comprises treating the adhesive such that its adhesive strength is lowered and removing the closure from the laboratory sample container.

Method for unsealing an opening of a laboratory sample container, method for handling a laboratory sample container, laboratory apparatus and laboratory automation system

A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

Automated system for processing particles

A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

Acceleration sensitive indicator

Growing community of inventors

Rotkreuz, Switzerland

Daniel Mueller