Massachusetts Institute of Technology

Illinois Tool Works Inc.

The Brigham and Women's Hospital, Inc.

Daniel Minahan

Carlo Giovanni Traverso

Andrew Bellinger

Tyler Grant

Taylor Bensel

Robert S Langer, Jr

Philippe Levesque

Malvika Verma

Miles Malone

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Resident articles for gram-level dosing

The present grip design includes a two-piece clamp with an interior space which forms a mold for the sample material. The two-piece clamp further includes undercut apertures which engage complementary tapered portions of upper and lower grips. The sample material can be poured to fill the mold formed within the two-piece clamp. The interior of the upper and lower grips includes a pattern, such as, but not limited to, a threaded pattern, in order to more firmly engage the sample. The samples may include soft materials, liquids, gels, compounds, powdered or similar materials. The grip may be used in connection with bioreactor or materials testing applications.

Molding grip fixture

Growing community of inventors

Weymouth, MA, United States of America

Daniel Minahan