Theravance, Inc.

Theravance Biopharma R&d Ip, LLC

Praxis Bioresearch, LLC

Advanced Medicine, Inc.

Daniel Marquess

Paul Ross Fatheree

Daniel D Long

S Derek Turner

Seok-Ki Choi

Adam Aaron Goldblum

Martin Sheringham Linsell

Roland Gendron

James Bradley Aggen

Edmund J Moran

Lan Jiang

Matthew B Nodwell

Sean Gary Trapp

Daniel G Genov

David C Green

Jason P Chinn

John H Griffin

Mathai Mammen

Robert Murray McKinnell

Thomas E Jenkins

Valentino J Stella

Timothy J Church

David A Oare

Jyanwei Liu

Ron H Bihovsky

YuHua Ji

Steven A Smith

Sandeep Patil

David Beattie

Scott Armstrong

Michael Robert Leadbetter

Kirsten M Phizackerley

Robert Murray Mckinnell

Sean M Dalziel

Ron Bihovsky

Steve Smith

Derek S Turner

Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Prodrugs of fencamfamine

Disclosed herein are pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives. The pharmaceutical compositions are for targeted therapeutic applications including, but not limited to, treating cancer-related fatigue, apathy in Alzheimer's Disease, major depression, and attention deficit-hyperactivity disorder. Also disclosed are methods of synthesizing the pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives.

The invention provides novel quinolinone-carboxamide 5-HTreceptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HTreceptor activity, and processes and intermediates useful for preparing such compounds.

Quinolinone-carboxamide compounds as 5-HT4 receptor agonists

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The invention relates to benzimidazole-carboxamide 5-HTreceptor agonist compounds of formula (I) wherein Rand X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HTreceptor activity, and processes and intermediates useful for preparing such compounds.

The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; Ris hydrogen, halo, hydroxy, Calkyl, or Calkoxy; Ris Calkyl, or Ccycloalkyl; Ris hydrogen or Calkyl: Ris S(O)Ror C(O)R; Ris hydrogen, Calkyl, Calkyl substituted with &#x2014;OH or Calkoxy, or &#x2014;CH-pyrydyl; Ris Calkyl; or Rand Rtaken together from Calkylenyl; and Ris hydrogen, Calkyl, or pyrydyl; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. 

This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Cross-linked glycopeptide-cephalosporin antibiotics

The invention provides novel indazole-carboxamide 5-HTreceptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HTreceptor activity, and processes and intermediates useful for preparing such compounds.

Indazole-carboxamide compounds

This invention provides cephalosporin compounds and salts thereof. Such compounds are useful for preparing cross-linked glycopeptide-cephalosporin antibiotics.

Cephalosporin compounds

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Half Moon Bay, CA, United States of America

Daniel Marquess