Wisconsin Alumni Research Foundation

Daniel Manson

Helen Blackwell

Modulation of quorum sensing in Gram-negative bacteria, particularly strains ofwhich form biofilms, by compounds including those of formula I and formula II: where:AR is optionally substituted phenyl, cycloalkyl or cycloalkenyl or heterocyclic, and Ris optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkylthioalkyl or alkyl substituted at the omega position with optionally substituted phenyl, cyclohexyl or cyclohexenyl. In particular compounds inhibit quorum sensing and biofilm formation. Pharmaceutical compositions for treatment of bacterial infections and methods of treatment of such infections are provided.

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Madison, WI, United States of America

Daniel Manson