University of Pennsylvania

Other

New York University

E. B. Michaels Research Associates, Inc.

Biosyn Inc. (a Pennsylvania Corporation)

Daniel Malamud

William R Abrams

Haim H Bau

Edwin B Michaels

Michael G Mauk

Harvey M Friedman

Changchun Liu

Earl Jim Bergey

Xianbo Qiu

Eran Geva

Mitchell Litt

Thandavarayan Nagashunmugam

Benjamin L Lewis

Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium&#x2014;such as a lateral flow strip&#x2014;where the user may label and detect the nucleic acids.

Isothermal nucleic acid amplification reactor with integrated solid state membrane

Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications

There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactivating sperm. There is provided articles for use in these methods.

Method for inactivating sexually transmitted enveloped viruses

The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.

Compositions and methods useful in treatment and prevention of HIV-1 infection

A remotely controlled drug delivery device administers a dose of a drug, agent or microbicide using a gas pressure delivery system. The device stores multiple doses of the drug or agent. A toroid shaped housing includes three chambers, a gas chamber containing a pressurized gas, a drug storage chamber containing the drug or agent, and an expandable chamber for delivering the drug from the drug storage. The device includes an electronic controller for opening a valve connecting the gas chamber to the expandable chamber for a predetermined period of time in order to deliver a predetermined dose of the drug. The controller communicates with a remote control device via radio frequency. The remote control device sends a signal to the controller, which causes a dose to be delivered. The controller returns a signal to the remote control device indicating that the dose has been delivered and a signal indicating when the device needs to be removed for maintenance. The device may be used in any body cavity to deliver any desired type of drug.

Remote control drug delivery device

There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactiviting sperm. There is provided articles for use in these methods.

Method for inactivating enveloped viruses and sperm

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New York, NY, United States of America

Daniel Malamud