American Home Products Corporation

Daniel M Teller

Alan R Davis

Michael D Lubeck

Kuo-Hom L Hsu

John H Sellstedt

Harry R Munson, Jr

Gunnar E Jagdmann, Jr

Ibrahim M Uwaydah

Donald P Strike

Arthur Attilio Santilli

Guy A Schiehser

Jehan F Bagli

Charles J Guinosso

Antiinfluenza A activity was found in compounds of the formula: ##STR1## wherein X is ##STR2## where one of R.sup.1 and R.sup.2 is H and the other is phenylamino and Z is --SCH.sub.3 or a pharmaceutically acceptable salt thereof.

N-cyanoamidine derivatives as anti-influenza agents

Antiinfluenza A activity was found in compounds of the formula: ##STR1## wherein: X is 2-phenylethyl, 2-furanylmethyl, or ##STR2## where one of R.sup.1 and R.sup.2 is H and the other is phenylamino; Z is --SCH.sub.3 when X is ##STR3## or ##STR4## when X is 2-phenylethyl or 2-furanylmethyl; or a pharmaceutically acceptable salt thereof.

Antiinfluenza A activity was found in compounds of the formula: ##STR1## wherein: X is 2-phenylethyl, 2-furanylmethyl, or ##STR2## where one of R.sup.1 and R.sup.2 is H and the other is phenylamino; Z is --SCH.sub.3 when X is ##STR3## when X is 2-phenylethyl or 2-furanylmethyl; or a pharmaceutically acceptable salt thereof.

Antiviral activity against respiratory syncytial virus has been found in some substituted 6-aminopyrimidines having the formula: ##STR1## wherein R.sup.1 is lower alkyl, preferably methyl or t-butyl, R.sup.2 is halogen or cyano, and R.sup.3 is C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n R.sup.4 where n is 1 or 2 and R.sup.4 is phenyl, phenyl substituted by lower alkoxy, lower alkyleneoxy, bromo, or 3,4-methylenedioxy; 3 or 4-pyridinyl, pyridinyl substituted by cyano or bromo, thienyl, or di-(C.sub.1 -C.sub.6 alkyl)amino.

Aminopyrimidine derivatives as antiviral agents for respiratory

A compound of the formula: ##STR1## in which A is a 3,4-; 3,2-; or 2,3-fused thieno- moiety or a benzo- moiety;

N-(pyridinylalkyl)-thieno-or benzo-isothiazol-3-amine derivatives

Orally active, antibacterial cephalosporin derivatives of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, compositions containing them and the process of using them are described.

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Columbus, OH, United States of America

Daniel M Teller