Myriad Genetics, Inc.

Alzheimer's Institute of America, Inc.

Daniel M Cimbora

Andrew Gassman

Tracey Cristine Fleischer

Vijay R Baichwal

Damon I Papac

Jeffrey S Flick

The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt); it also relates to therapeutic methods that utilize Nampt inhibitors in combination with NAD biosynthesis precursors to intentionally kill cancer cells while limiting or minimizing toxicity to normal host cells; and it relates to methods of identifying cancers that will be most responsive to treatment with Nampt inhibitors, particularly when administered in combination with nicotinic acid.

Therapeutic and diagnostic methods

Protein complexes are provided comprising FAP48 and one or more FAP48-interacting proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with FAP48 and its interacting partners. In addition, methods of detecting the protein complexes and modulating the functions and activities of the protein complexes or interacting members thereof are also provided.

FAP48-interacting proteins and use thereof

Growing community of inventors

Salt Lake City, UT, United States of America

Daniel M Cimbora