Illumina Corporation

Illumina Cambridge Limited

Daniel Leonard Fuller

Bradley Kent Drews

Mark J Nibbe

James Christopher Blake

Gudrun Stengel

Oliver Jon Miller

Michael Steven Becker

Mohammed Kafeel Ahamed

Michael Thomas Dangelo

Tarun Kumar Khurana

Yir-Shyuan Wu

Paul Crivelli

Cyril Delattre

Behnam Javanmardi

Brian Douglas Mather

Xavier Von Hatten

Filiz Gorpe-Yasar

Andrew Joad

Michael Dangelo

Pallavi Daggumati

Sebastien Georg Gabriel Ricoult

The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.

Liquid sample loading

In the examples set forth herein, nucleic acid extraction materials are capable of selectively extracting cell free nucleic acids, including cell free DNA, directly from whole blood samples or plasma. Also included are methods of making and using the nucleic acid extraction materials. One example of a nucleic acid extraction material includes a substrate. This example of the nucleic acid extraction material also includes a polycation bonded to at least a portion of a surface of the substrate. In this example, the polycation consists of a polymer of a quaternized monomer selected from the group consisting of a quaternized 1-vinylimidazole monomer and a quaternized dimethylaminoethyl methacrylate monomer, or a copolymer of a neutral monomer and the quaternized monomer.

Nucleic acid extraction materials, systems, and methods

Disclosed are multi-well plate inserts that can be used to separate solid debris, including paper punch containing a blood sample, from a liquid containing target biological molecules, such as nucleic acid molecules and proteins. Also provided are methods of using the insert, for example as part of a method that analyzes target biological molecules.

Multi-well plate adaptors

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Sudbury, United Kingdom

Daniel Leonard Fuller