Aston University

Insight Health Limited

Daniel Lee Rathbone

Tony Worthington

Sahar Al-Malaika

Matthew Justin Hird

Alexandria Rose Quayle

Martin Griffin

Leonas Eduard Badarau

The invention relates to compounds, compositions and polymers comprising a first component adapted to promote germination of() and a second component which acts as an antimicrobial agent. Said compounds, compositions and polymers are useful for destroyingwhere conventional antimicrobial agents are unsuccessful. The compositions can be formulated as coating or materials which actively destroywhich come into contact with it. The germination promotion is induced by bile salts. The invention also relates to the use of such materials as a treatment forassociated diseases and toxic megacolon.

Compound for treating clostridium difficile

The present invention relates to novel compounds of Formula I capable of inhibiting tissue transglutaminase, and uses of the same in medicine. In particular, the invention provides compounds for use in the treatment of prevention of disease and conditions such as fibrosis (e.g. cystic fibrosis), scarring, neurodegenerative diseases (e.g. Alzheimer's disease, Huntington's disease and Parkinson's disease), autoimmune diseases (e.g. multiple sclerosis and coeliac disease), thrombosis, proliferative disorders (e.g. cancers), AIDS, psoriasis and inflammation (e.g. chronic inflammatory diseases).

Acylpiperazines as inhibitors of transglutaminase and their use in medicine

Growing community of inventors

West Midlands, United Kingdom

Daniel Lee Rathbone