Eli Lilly and Company

Daniel Lawrence Hartman

Brian W Grinnell

Sau-Chi Betty Yan

A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, , meningococcal sepsis, bone marrow and other transplantations, severe burns, pregnancy, major surgery, severe trauma, or ARDS, which comprises administering activated protein C providing a highly selective therapeutic agent with a low potential for causing bleeding complications.

Method of reducing mortality in severe sepsis

A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans, meningococcal sepsis, bone marrow and other transplantations, severe burns, pregnancy, major surgery, severe trauma, or ARDS, which comprises administering activated protein C providing a highly selective therapeutic agent with a low potential for causing bleeding complications.

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Indianapolis, IN, United States of America

Daniel Lawrence Hartman