Analytical Bio-chemistry Laboratories, Inc.

Daniel L Newhouse

Leemer G Cernohlavek

Philip D Lochhaas

Ralph H Waltz

Richard G Wheeler

Automated gel permeation chromatography of multiple individual samples is effected with high precision and high speed utilizing a common sample sizing loop into which each sample is placed prior to its injection into the chromatography column, thereby eliminating the need for precisely matched sample loops. Each sample is pre-stored in its own container, the containers being automatically sequentially accessed to feed a portion of the contained sample medium to the common sample sizing loop. The common sample flow path, including the sample sizing loop, is automatically cleaned with rinse solvent between loading of successive samples into the sizing loop. Multiple programs may be employed to control the processing times for different types of sample fluid. A sample container closure member having a unique sealing insert member is provided to preclude leakage of fluid from the sample storage container when the container is pressurized.

Apparatus for supporting a container for fluid material

Automated gel permeation chromatography of multiple individual samples is effected with high precision and high speed utilizing a common sample sizing loop into which each sample is placed prior to its injection into the chromatography column, thereby eliminating the need for precisely matched sample loops. Each sample is pre-stored in its own container, the containers being automatically sequentially accessed to feed a portion of the contained sample medium to the common sample sizing loop. The common sample flow path, including the sample sizing loop is automatically cleaned with rinse solvent between loading of successive samples into the sizing loop. Multiple programs may be employed to control the processing times for different types of sample fluid. A sample container closure member having a unique sealing insert member is provided to preclude leakage of fluid from the sample storage container when the container is pressurized.

Single-loop chromatography system and method

In a microprocessor-controlled evaporation/concentration system, a plurality of sample solutions are automatically successively delivered to an evaporation chamber. Each sample solution is evaporated in successively delivered slug components. The underside of the bottom wall is maintained at a microprocessor-determined constant evaporation temperature by an electrical resistance heater and proportional temperature controller. Pressure in the chamber is maintained substantially on the vapor pressure versus temperature curve of the sample solution, thereby assuring a known evaporation rate. Valving controlled by the microprocessor permits automatic addition of diluent to the chamber. The prepared sample is then automatically transferred to one of multiple storage vials which are brought into successive registration with a syringe needle assembly by means of a rotatable vial storage tray. The microprocessor automatically cleanses the entire flow system with cleansing solution and/or purging gas after each sample has been evaporated/concentrated.

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Harrisburg, MO, United States of America

Daniel L Newhouse