US Government As Represented by the Secretary of the Army

Other

Daniel L Klayman

John P Scovill

Carl J Mason

T Scott Griffin

Joseph F Bartosevich

Ai Jeng Lin

John Charles Drach

Wilbur K Milhous

Max Grogl

Kenneth E Kinnamon

Charles Shipman, Jr

Maurice M Iwu

Sandra H Smith

Joan E Jackson

Arthur S Dobek

John D Tally

Norman E Morrison

Armando Gonzalez

Steven L Andersen

Steven D Grant

John W McCall

Samuel P Massie

Charles F Franchino

A method of preparing substantially purified alkaloids from seeds, stems, uit-rind and bark of a plant selected from Picralima nitida, Gongronema latifolia, Dorstenia multiradiata, Cola attiensis, Rothmania withfieldii and Desmodium gangeticum, for use in the treatment of protozoal diseases, comprising:

Alkaloids of picralima nitida used for treatment of protozoal diseases

This invention is directed to heterocyclic and aromatic thiosemicarbazones seful in the treatment of filariasis and in an animal, including humans.

Heterocyclic and aromatic thiosemicarbazones useful in the treatment of

This invention relates to novel dihydroartemisinin derivatives, including their pharmaceutically-acceptable salts, which are therapeutically-effective in the pre- and post-treatment of malarial infections.

Novel antimalarial dihydroartemisinin derivatives

This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

2-acetyl-and 2-propionylpyridine thiosemicarbazones

This invention relates to novel 2-acetyl- and 2-propionylpyridine selenosemicarbazones. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the selenosemicarbazones.

2-acetyl- and 2-propionylpyridine selenosemicarbazones

This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones and their selenium analogs.

Transition metal complexes of the selenium analogs of 2-acetyl- and

This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

2-acetylpyridine thiosemicarbazones as antiviral agents

Medicinal 2-acetyl- and 2-propionylpyridine thiosemicarbazones and

Method for treating bacterial infections with 2-acetyl- and

This invention relates to the preparation and use of various 2-acetyl quiine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infections, such as leprosy and meningitis.

2-Acetyl quinoline thiosemicarbazones useful in treatment of gonorrhea,

This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Method for treating gonorrhea infections with 2-acetyl- and

2-Acetyl-and 2-propionylpyridine thiosemicarbazones as antimalarials

2-Acetyl-and 2-propionylpyridine thiosemicarbazones

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Chevy Chase, MD, United States of America

Daniel L Klayman