University of California

Daniel L Clemens

Marcus Aaron Horwitz

Bai-Yu Lee Clemens

Chih-Ming Ho

Christopher Lewis Bradley

Henry Vernon Oppermann

Xianting Ding

Aleidy Marlene Silva Vite

Theodore Kee

Jr Murnane Robert M

Jeffrey I Zink

Qingmei Jia

Bastian Ruehle

In various embodiments nanoparticle drug delivery vehicles are provided that specifically deliver a cargo to a target pathogenic organism. In certain embodiments the drug delivery vehicle comprises a mesoporous silica nanoparticle comprising a plurality of pores and an outer surface through which the pores are disposed; a cargo disposed in the pores; one or more antigens attached to the surface of the nanoparticle; an antibody that specifically binds the antigens and are bound to the antigens, wherein the antibody inhibits diffusion of the cargo out of the pores and permit release of the cargo when the drug delivery vehicle is in the presence of the antigen or a pathogen displaying the antigen.

Pathogen-specific cargo delivery and diagnostic platform based on mesoporous silica nanoparticles

The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Multi-drug therapies for tuberculosis treatment

The disclosure provides an antigenic composition useful for immunization against tularemia. The disclosure provides a method for producing a vaccine for preventing tularemia in humans and animals, a new vaccine against tularemia in humans and animals, and a new approach to producing vaccines against tularemia.

Methods and compositions for treating tularemia

A method and composition are provided for treating intracellular pathogens that reside in phagosomes. The compositions include antibiotics which are conjugated with transferrin or other ligands to form conjugates that target membrane-bound pathogens. The conjugates are selectively taken up by infected phagosomes. Conjugates are provided which utilize transferrin as the targeting ligand for treating mycobacterium which reside in membrane-bound phagosomes.

Anti-microbial targeting for intracellular pathogens

Growing community of inventors

Los Angeles, CA, United States of America

Daniel L Clemens