Rhone-poulenc Rorer Pharmaceuticals Inc.

Daniel L Cheney

William R Ewing

Alfred P Spada

Michael R Becker

Henry W Pauls

Christopher J Burns

Raymond D Youssefyeh

Yong Mi Choi-Sledeski

John W Ullrich

Jonathan S Mason

Jonathan Stephen Mason

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

Substituted (sulfinic acid, sulfonic acid, sulfonylamino or

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.

Azacyclic bisphosphonates as anticholesterolemic agents

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West Chester, PA, United States of America

Daniel L Cheney