Bristol-myers Squibb Compnay

Daniel L Cheney

Eldon Scott Priestley

Nicholas Ronald Wurtz

Jian Chen

Peter W Glunz

Xiaojun Zhang

Thomas C Nelson

Vladimir Ladziata

Brandon Lee Parkhurst

Uwe D Treuner

Yan Shi

Gregory S Bisacchi

William A Slusarchyk

James Clifford Sutton

Jon J Hangeland

Shung C Wu

Guohua Zhao

Todd J Friends

Jeremy M Richter

Luciano Mueller

J Alex Bates

Donna A Bassolino

The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments. 

Macrocyclic factor VIIa inhibitors

The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z, Z, Z, Z, R, R, R, R, R, R, R, R, R, and Rare as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

Macrocyclic factor VIIa inhibitors useful as anticoagulants

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z, Z, Z, Z, R, and Rare as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

Bicyclic lactam factor VIIa inhibitors useful as anticoagulants

The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R, R, R, R, R, R, R, R, R, and Rare as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.

Compounds of formula I its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in treating calcium channel-dependent disorders, including hypertension.

Sulfonyl amide inhibitors of calcium channel function

The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01

Acid derivatives useful as serine protease inhibitors

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Ringoes, NJ, United States of America

Daniel L Cheney