Los Gatos Research, Inc.

Metabolic Solutions, Inc.

Daniel L Bolt

David A Wagner

Manish P Gupta

Douglas Steven Baer

Susan Lauren Fortson

Elena Simone Franklin Berman

Keith J Goodman

Biological fluid samples containing proteins (e.g., blood plasma or saliva) are prepared for isotopic analysis by precipitating the proteins while leaving the isotopic ratio unaffected. This precipitation can involve adding metal ions, salts, organic solvents, or organic polymers. The sample is then centrifuged to allow transfer of the supernatant for isotopic analysis, e.g. by tunable diode laser absorption spectrometry to obtain a quantitative measure of theH andO isotope levels in the water relative to reference standards.

Method for isotopic analysis of water in bodily fluids

A meat-free, algae-free, standardized, test meal kit used in the measurement of delayed gastric emptying is provided. The kit contains at least a standardized test meal dry mix and tracer. A method of using the kit is also provided.

Measurement of gastric emptying

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Medford, MA, United States of America

Daniel L Bolt