Eli Lilly and Company

Daniel Kurt Cashion

Gang Chen

Wei Zhang

Joseph C Walsh

Hartmuth C Kolb

Changhui Liu

Chul Yu

Umesh B Gangadharmath

Dhanalakshmi Kasi

Vani P Mocharla

Eric Wang

Anna Katrin Szardenings

Anjana Sinha

Peter J H Scott

Vani P Mocharia

Peter Jh Scott

Peter JH Scott

Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and &#x3b2;-amyloid peptides are presented herein. The invention also relates to methods of imaging A&#x3b2; and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Imaging agents for detecting neurological disorders

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Manhattan Beach, CA, United States of America

Daniel Kurt Cashion