Universitaet Leipzig

Amp-Therapeutics Gmbh

Universitat Leipzig

Daniel Knappe

Ralf Hoffmann

Serge Ruden

Kai Hilpert

Ralf Mikut

Anna Klara Brigitte Hansen

This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as According to the invention, the object is attained in a first aspect by a peptide according to claim

Modified apidaecin derivatives as antibiotic peptides

This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as According to the invention, the object is attained in a first aspect by a peptide according to claim

The present invention relates to a antimicrobial peptide or peptide derivative comprising the following sequence: Sub-X-D-K-P-P-Y-L-P-R-P-X-P-P-R-X-T-P-N-N-X-Sub. The invention further relates to multimers comprising said peptides or peptide derivatives. Moreover, the invention provides a peptide or peptide derivative for use in the treatment of a disease. The peptide or peptide derivative may also be used in the screening for novel antimicrobial compounds.

[object Object]

The invention relates to a peptide or peptide derivative having the general formula: Sub-X-DK-P-P-Y-L-P-R-P-X-P-P-R-X-I-P/Y-N-N-X-Sub, wherein Xis a non-polar, hydrophobic group or a positively charged group, Dis asparagine or glutamine, K, X, and Xare positively charged groups, Xis a positively charged group, proline, or a proline derivative; Land Iare non-polar, hydrophobic groups, Yand Yare tyrosine, Rand Rare arginine, Nand Nare asparagine or glutamine, P, P, P, P, P, P, and Pare proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D, P, P, P, P, P, P, P, and Yare replaced by an arbitrary group and/or Pand Rare exchanged, Subis the free or modified N-terminus, and Subis the free or modified C-terminus. The invention further relates to the use of the peptides and peptide derivatives in medicine, as an antibiotic, in a disinfectant or cleaning agent, as a preservative or in a packaging material, in pharmaceutical research, or in a screening method.

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Leipzig, Germany

Daniel Knappe