The Charles Stark Draper Laboratory, Inc.

Massachusetts Institute of Technology

Drãgerwerk Ag & Co, Kgaa

University of Texas System

The General Hospital Corporation

Daniel Kenneth Freeman

Amy Elizabeth Duwel

James Alan Bickford

Louis Kratchman

Marc Steven Weinberg

Jonathan Jay Bernstein

Paul A Ward

Bryan McLaughlin

William David Sawyer

Stephanie Lynne Golmon

Anilkumar Harapanahalli Achyuta

Ronald Steven McNabb, Jr

Ronald Gatzke

Andrew Czarnecki

James S Pringle, Jr

Brett Ingersoll

Brian Daniels

Reed Irion

William A Lenk

Max Lindsay Turnquist

Jeffrey T Borenstein

Matthew Scot Rosen

Jonathan Robert Coppeta

Paulo C Lozano

Melissa Alyson Smith

Donna-Ruth Webb Yost

Mario Romero-Ortega

Vishal Tandon

Jesse J Wheeler

John Francis Barry

Danielle Ann Braje

Stuart F Cogan

John Joseph LeBlanc

Laura Jane Mariano

Jenna Leigh Balestrini

Daniel Joseph Guyon

John J Le Blanc

Matthew Steinecker

Jessica Kedziora

Jonathan Michael O'Brien

Noah Siegel

Reed Anderson Irion

Circuits are provided for detecting an electrosurgical unit signal. An example circuit includes: a filter configured to process a floating ground signal associated with measuring a bio-potential signal of a patient, and a detector configured to output a sensing signal based at least in part on the floating grounding and the Earth ground for detecting an electrosurgical unit signal.

Circuits and methods for electrosurgical unit signal detection

Ferrimagnetic oscillator magnetometers do not use lasers to stimulate fluorescence emission from defect centers in solid-state hosts (e.g., nitrogen vacancies in diamonds). Instead, in a ferrimagnetic oscillator magnetometer, the applied magnetic field shifts the resonance of entangled electronic spins in a ferrimagnetic crystal. These spins are entangled and can have an ensemble resonance linewidth of approximately 370 kHz to 10 MHz. The resonance shift produces microwave sidebands with amplitudes proportional to the magnetic field strength at frequencies proportional to the magnetic field oscillation frequency. These sidebands can be coherently averaged, digitized, and coherently processed, yielding magnetic field measurements with sensitivities possibly approaching the spin projection limit of 1 attotesla/&#x221a;{square root over (Hz)}. The encoding of magnetic signals in frequency rather than amplitude relaxes or removes otherwise stringent requires on the digitizer.

Ferrimagnetic oscillator magnetometer

Electrospray devices and methods of fabricating electrospray devices are described.

Electrospray devices and methods for fabricating electrospray devices

Aspects are generally directed to a compact and low-noise electric field detector, methods of operation, and methods of production thereof. In one example, an electric field detector includes a proof mass, a source of concentrated charge coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The electric field detector further includes a sense electrode disposed on the substrate within the substrate offset space and proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received electric field at the source of concentrated charge. The electric field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the electric field based on the measured change in capacitance.

Miniature electric field detector

A method and system of delivering a charged cargo, such as a biomolecule, to a target structure, such as cells, exosomes, other vesicles or micelles, using an electroactive porous membrane. This method comprises contacting an electroactive porous membrane with a fluid flow toward the membrane. The fluid contains charged biomolecules and the membrane and biomolecules are oppositely charged so that the biomolecules in the fluid are trapped on the membrane as the fluid flows through the pores of the membrane. Acceptor cells of interest are pinned to the membrane by the flow of the fluid, thereby aggregating the cells onto the membrane in close proximity to the trapped biomolecules. Finally, the acceptor cells are permeabilized.

Method and system for incorporation of biomolecules into vesicles, cells, and micelles using electroactive porous device membrane

This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Neural implant for microstimulation

A system for providing biphasic stimulation is disclosed. The system includes an electrode, an antenna coupled to a transmitter, a capacitor, a power supply, a backscatter load selectively coupled to the antenna via a switching device, a plurality of switches, and a controller configured to control the switching device to output, by the antenna, an acknowledgement signal to the transmitter responsive to receiving the power. The controller is further configured to control the plurality of switches to electrically couple a first plate of the capacitor to the electrode to provide a first nerve stimulation signal having a first polarity, and electrically couple a second plate of the capacitor to the electrode to provide a second nerve stimulation signal having a second polarity opposite the first polarity. The system further includes a housing encapsulating the antenna, the capacitor, the power supply, the backscatter load, the switches, and the controller.

Integrated circuit design for wireless control of biphasic stimulation in bioelectronic implant

Circuits are provided for detecting an electrosurgical unit signal. An example circuit includes: a filter configured to process a floating ground signal associated with measuring a bio potential signal of a patient, and a detector configured to output a sensing signal based at least in part on the floating grounding and the Earth ground for detecting an electrosurgical unit signal.

In one aspect, implantable wireless microstimulators are described herein. In some embodiments, a microstimulator described herein includes an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. The microstimulator further comprises a diode rectifier in series with the energy harvesting circuit. The diode rectifier is configured to rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. Additionally, in some cases, an electrical interface is exposed through the biocompatible electrically insulating material. A microstimulator described herein can also include a nerve cuff. The nerve cuff can be configured to receive a monophasic neural stimulation pulse through the electrical interface of the micro stimulator. Moreover, the nerve cuff can be placed around a targeted peripheral nerve to provide a monophasic stimulation pulse to the peripheral nerve.

Implantable wireless microstimulator for peripheral nerves

Aspects are generally directed to systems and methods that integrate contactless electric field detectors to measure biophysical signals generated by a body. In one example, a biophysical sensing system includes a sensing assembly including an array of contactless electric field detectors, each of the contactless electric field detectors being configured to sense a corresponding component of an electric field generated by a body, a control system to receive sensor data indicative of the components of the electric field sensed by each of the contactless electric field detectors, the control system being configured to generate an estimate of the electric field based on the sensor data, and a feedback system coupled to at least the control system, the feedback system including at least one feedback interface, the feedback system being configured to operate the feedback interface to provide feedback based on the estimate of the electric field.

Biophysical sensing systems and methods using non-contact electric field detectors

A system and method for imaging in connection with electrical currents includes nanoparticles introduced into a region in which the electrical currents are present. A low-field magnetic resonance imaging (MRI) scanner detects an effect of a magnetic field generated by interaction of the nanoparticles with the electrical currents in the region. The MRI scanner operates at a magnetic field intensity below a level at which the nanoparticles would be magnetically saturated.

Apparatus and method for imaging currents using nanoparticles and low-field magnetic resonance imaging (MRI)

Growing community of inventors

Reading, MA, United States of America

Daniel Kenneth Freeman