Depuy Synthes Products, Inc.

Codman & Shurtleff, Inc.

Daniel Keeley

Terri Kapur

Michael J O'Neil

Greg M Schorn

Nimish Parikh

Liesbeth Brown

John R Hoofnagle

Shannon Cormier

Schorn Greg

Shannon Webster

Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.

Aspirating implants and method of bony regeneration

A method of delivering a therapeutic fluid to the tissue of a mammal using pulsatile flux to prevent fluid backflow.

Pulsatile flux drug delivery

A therapeutic agent delivery system that includes a catheter having a proximal end and an opposite distal end. The catheter has a body with a lumen defined therein. The body of the catheter includes a non-bulbous region having a substantially uniform outer diameter and a bulbous region made from an elastically deformable material. While in a first state the bulbous region has a maximum outer diameter greater than the substantially uniform outer diameter of the non-bulbous region; and while in a second state the maximum outer diameter of the bulbous region is reduced relative to that while in the first state.

Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent

A catheter for delivery of a therapeutic agent directly into a targeted tissue that reduces or substantially prevents reflux and back flow by providing rigidity and strength via a stylet thereby eliminating the need for a guide or delivery sheath during positioning. The catheter has a flexible proximal section and a substantially rigid distal section formed from a plurality of distal subsections. The proximal and distal sections having decreasing outer diameters starting from the proximal end and advancing towards the distal end. The distal subsection closest to the distal end providing an adjustable flow rate via multiple output ports defined radially therein while the distal end itself is closed off.

Growing community of inventors

Boston, MA, United States of America

Daniel Keeley