Bayer Corporation

Miles Inc.

Aerovance, Inc.

Daniel K Muller

Katherine A Delaria

Paul P Tamburini

Gary Davis

Christopher W Marlor

Elise Brownell

Linda Wallace

The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.

Human bikunin

The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof

Cytotoxic T-lymphocyte antigen as cysteine protease inhibitor

Disclosed are molecules which inhibit the proteolytic activity of cysteine proteases such as Cathespin H, Cathespin L and papain, and methods for using molecules which have the biological properties of cytotoxic T-lymphoyte antigen for inhibiting cysteins proteases and inhibiting proteolglycan degradation.

This invention concerns methods of treating mast-cell mediated conditions in mammals, the methods comprising administering to the mammals pharmacologically active fragments or muteins of SLPI; methods of treating asthma or allergic rhinitis in mammals, the methods comprising administering to the mammals SLPI or pharmacologically active fragments or muteins thereof; methods for inhibiting tryptase; methods for identifying inhibitors of tryptase; and certain fragments and muteins of SLPI.

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Orange, CT, United States of America

Daniel K Muller