National Institutes of Health, a Component of the US Dept. of Health & Human Services

Daniel Joseph Mollura

Le Lu

Ronald M Summers

Adam Patrick Harrison

Ziyue Xu

Methods include processing image data through a plurality of network stages of a progressively holistically nested convolutional neural network, wherein the processing the image data includes producing a side output from a network stage m, of the network stages, where m&#x3e;1, based on a progressive combination of an activation output from the network stage m and an activation output from a preceding stage m&#x2212;1. Image segmentations are produced. Systems include a 3D imaging system operable to obtain 3D imaging data for a patient including a target anatomical body, and a computing system comprising a processor, memory, and software, the computing system operable to process the 3D imaging data through a plurality of progressively holistically nested convolutional neural network stages of a convolutional neural network.

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Chevy Chase, MD, United States of America

Daniel Joseph Mollura