International Business Machines Corporation

Agency for Science, Technology and Research

Globalfoundries Inc.

King Abdulaziz City for Science and Technology

Daniel Joseph Coady

James L Hedrick

Yi Yan Yang

Amanda Catherine Engler

Kazuki Fukushima

Jeannette M Garcia

Richard Anthony Dipietro

Alshakim Nelson

Hans Werner Horn

Victor W L Ng

Jeremy P K Tan

Zhan-Yuin Ong

Urs T Duerig

Armin W Knoll

Chuan Yang

Jane Elizabeth Frommer

Julia Elizabeth Rice

Julian M W Chan

Shaoqiong Liu

Gregory Breyta

Wei Han

Robert J Ono

Wei Cheng

Mu San Zhang

Jed Walter Pitera

Ashlynn L Z Lee

Hareem Tariq Maune

Shrinivas Venkataraman

Pei Yun Teo

Steven J Holmes

Matthew Earl Colburn

Phillip Joe Brock

Joy Cheng

Richard Anthony DiPietro

Fares D Alsewailem

Gavin O Jones

Willy Chin

Blake W Davis

Ashlynn Lingzhi Lee

Jye Yng Teo

Xiyu Ke

Haritz Sardon

Zhan Yuin Ong

Hamid A Almegren

Jeremy Pang Kern Tan

Abdullah M Alabdulrahman

Jeremy Pk Tan

Shao Qiong Liu

Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Antimicrobial cationic polycarbonates

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

Condensation polymers for antimicrobial applications

A cationic star polymer is disclosed of the general formula (1): wherein w' is a positive number greater than or equal to 3, I&#x2032; is a dendritic polyester core covalently linked to w&#x2032; independent peripheral linear cationic polymer chains P&#x2032;. Each of the chains P&#x2032; comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.

Cationic polymers for antimicrobial applications and delivery of bioactive materials

Eight-membered ring cyclic carbonates comprising a ring nitrogen at position 6 (1,3,6-dioxazocan-2-ones) were prepared by reaction of precursor diols with active carbonates. The ring nitrogen is linked to a pendant group Y' via a methylene linking group. The cyclic carbonates undergo organocatalyzed ring opening polymerization to form an initial polycarbonate comprising a backbone tertiary amine group. Quaternization of the initial polycarbonates forms cationic polycarbonates comprising a positive-charged backbone quaternary nitrogen. The cationic polycarbonates can be potent antimicrobial agents.

1,3,6-dioxazocan-2-ones and antimicrobial cationic polycarbonates therefrom

A poly(aryl ether sulfone) of low polydispersity containing no detectable cyclic polymer byproduct was prepared by melt polymerization without catalyst, solvent, and base. The poly(aryl ether sulfone) can be used without further purification for the manufacture of articles. A melt composition for fabricating an article comprises the poly(aryl ether sulfone) and, optionally, one or more additives.

Methods of forming poly(aryl ether sulfone)s and articles therefrom

Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.

Water soluble polycarbonates for medical applications

The invention concerns a method for patterning a surface of a material. A substrate having a polymer film thereon is provided. The polymer is a selectively reactive polymer (e.g., thermodynamically unstable): it is able to unzip upon suitable stimulation. A probe is used to create patterns on the film. During the patterning, the film is locally stimulated for unzipping polymer chains. Hence, a basic idea is to provide a stimulus to the polymeric material, which in turn spontaneously decomposes e.g., into volatile constituents. For example, the film is thermally stimulated in order to break a single bond in a polymer chain, which is sufficient to trigger the decomposition of the entire polymer chain.

Patterning nano-scale patterns on a film comprising unzipping copolymers

A branched polyamine comprises about 8 to about 12 backbone tertiary amine groups, about 18 to about 24 backbone secondary amine groups, a positive number n' greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n&#x2032;+q) is a number equal to about 8 to about 12, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L&#x2032; is a divalent linking group comprising 3 to 30 carbons, and q/(n&#x2032;+q)&#xd7;100% equals about 9% to about 40%.

Low molecular weight branched polyamines for delivery of biologically active materials

Cationic, anionic, and/or zwitterionic bis-urea compounds self-assemble by non-covalent interactions in aqueous solution to form high aspect ratio nanofibers. The nanofibers reversibly bind drugs by non-covalent interactions, forming drug compositions for exhibiting sustained release of the drug.

Self-assembling bis-urea compounds for drug delivery

One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.

Catalyst-free methods of forming polyurethanes from pentafluorophenyl carbonates

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San Jose, CA, United States of America

Daniel Joseph Coady