Cyberonics, Inc.

Neurovista Corporation

Other

Dilorenzo Biomedical, LLC

Bioneuronics Corporation

Daniel John DiLorenzo

Kent W Leyde

The present invention provides systems and methods for managing epilepsy. In one embodiment, a method of the present invention characterize a patient's propensity for a future epileptic seizure and communicates to the patient and/or a health care provider a therapy recommendation. The therapy recommendation is typically a function of the patient's propensity for the future epileptic seizure.

Methods and systems for managing epilepsy and other neurological disorders

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a 'nervous system component.' The neurological control system generates neural modulation signals delivered to a nervous system component through one or more intracranial (IC) stimulating electrodes in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease

Systems and methods for monitoring an epilepsy disease state in a human patient are described. The system includes patient components and a supervisory module. The patient components include: an implantable electrode array for collecting neurological signals, an implantable recording electrode signal processor for processing the neurological signals collected by the electrode array, and a disease state estimator for estimating the patient's disease state. The supervisory module receives the patient's disease state from the patient components and displays a time history of the patient's disease state.

Monitoring an epilepsy disease state with a supervisory module

The present invention provides a system for providing neurological disease state information to a patient. The system comprises one or more sensors that sense at least one signal that comprise feature(s) that are indicative of a neurological disease state. A signal processing assembly is in communication with the one or more sensors and processes the at least one signal to estimate the neurological disease state. A patient interface module is in communication with the signal processing assembly and communicates with a patient an output that is indicative of the patient's estimated neurological disease state.

Systems and methods for monitoring a patient's neurological disease state

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a 'nervous system component.' The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) and peripheral stimulating electrodes and other actuators, in accordance with treatment parameters. The neurological control system may directly or indirectly control a portion of the autonomic nervous system, including the sympathetic and parasympathetic nervous system. Such treatment parameters may be derived from a neural or physiological response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Closed-loop feedback-driven sympathetic neuromodulation for affect control

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a 'nervous system component.' The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Methods and systems for determining subject-specific parameters for a neuromodulation therapy

Methods and systems for continuous EEG monitoring

The present invention provides a closed-loop system for treating neurological disorders, such as epilepsy. In one embodiment the system comprises an input assembly that is adapted to receive one or more signals from a patient that are indicative of a patient's neurological state. The input assembly processes the one or more signals to generate one or more control input signals. An output assembly receives the one or more control input signals from the input assembly and generate a neuromodulation signal that is a function of the patient's neurological state. An electrode array is configured to deliver the neuromodulation signal to a patient's peripheral nerve, such as the vagus nerve.

Closed-loop vagus nerve stimulation

The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.

Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders

The present invention provides methods and systems for modulating a patient's neurological disease state. In one embodiment, the system comprises one or more sensors that sense at least one signal that comprise a characteristic that is indicative of a neurological disease state. A signal processing assembly is in communication with the one or more sensors and processes the at least one signal to estimate the neurological disease state and to generate a therapy to the patient that is based at least in part on the estimated neurological disease state. A treatment assembly is in communication with the signal processing assembly and delivers the therapy to a nervous system component of the patient.

Systems for monitoring a patient's neurological disease state

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a 'nervous system component.' The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) stimulating electrodes and other actuators, in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Closed-loop feedback-driven neuromodulation

Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders

Methods and systems for monitoring a subject's brain activity are provided. A method includes receiving EEG signals from the subject using a plurality of EEG electrodes positioned extracranially; and recording EEG signals using a recording circuit coupled to said EEG electrodes and contained in an enclosure implanted beneath the subject's scalp and above the subject's caldarium.

Extracranial monitoring of brain activity

A neurological control system for modulating activity of any component or structure of some or all of the nervous system, or any structure interfaced thereto, generally referred to herein as a 'nervous system component.' This system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state or autonomic state and prevent neurological or metabolic signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals, with sensors configured to sense a particular characteristic indicative of a neurological, psychiatric, or metabolic condition.

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Seattle, WA, United States of America

Daniel John DiLorenzo