USA As Represented by Secretary of the Navy

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Genvec, Inc.

Epimmune Inc.

Pharmexa Inc.

Daniel John Carucci

Imre Kovesdi

Duncan L McVey

Joseph T Bruder

C Richter King

Denise Louise Doolan

Douglas E Brough

Martha Sedegah

Keith Limbach

Joao Carlos Aguair

Walter R Weiss

Alessandro D Sette

John Sidney

Scott Southwood

Damodar R Ettyreddy

Denise L Doolan

The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.

Malaria antigen screening method

The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such asnucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.

Adenoviral vector-based malaria vaccines

The subject invention provides novelantigens and novel polynucleotides encoding these antigens. Also provided by the subject invention are methods of using these antigens and polynucleotides.

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Washington, DC, United States of America

Daniel John Carucci