The Governors of the University of Alberta

Harvard College

Daniel Jed Harrison

Adam Ezra Cohen

Robert Earl Campbell

Daniel Hochbaum

Peng Zou

Samouil Leon Farhi

Yongxin Zhao

Richard H Smith

Per Andersson

Paul C H Li

Roderick Szarka

Hossein Salimi-Moosavi

Aaron Neufeld

Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.

Optogenetic probes for measuring membrane potential

This invention relates to a novel microfluidic device and methods of using this device to conduct in vitro studies on the reaction and effects of various compounds on cells. More particularly, it relates to a method for using stop flow in a microfluidic system to study the effect of compounds on individual cells. It also provides a method for observing the effects of candidate compounds on leukocyte rolling.

Microfluidic system and methods of use

This invention relates to a novel microfluidic device and methods of using this device to conduct in vitro studies on the reaction and effects of various compounds on cells. More particularly, it relates to a method for using stop flow in a microfluidic system to study the effect of compounds on individual cells.

Ion selective membranes and ion selective electrode constructions which include ethylene vinyl acetate (EVA), a reduced amount of plasticizer and an ion selective material. The ion selective membranes have a low crystallinity. In certain embodiments, the ion selective membranes may further include polyvinyl chloride (PVC), a salt or a combination thereof. The ion selective membrane can be incorporated into an ion selective electrode construction. Methods of manufacturing the ion selective membranes and ion selective electrode constructions are provided.

Eva containing ion selective membranes and methods of making same

Growing community of inventors

Edmonton, Canada

Daniel Jed Harrison