The B. F. Goodrich Company

Noveon IP Holdings Corp.

Pmd Holdings Corp.

Daniel James Adams

David William Weaver

Zahid Amjad

Carl J Long, Ii

Solomon Lemma

Jian-Hwa Guo

William Robert Wilber

Edward S Greenberg

The present invention pertains to a method for forming polyacrylic acid granules and granules formed therefrom wherein the granules are flowable, have an increased bulk density relative to the as polymerized polyacrylic acids, and a low amount of dust which is generally characterized herein as particles which pass through a 325 mesh screen. The granules formed by the method of the present invention can be used to prepare controlled release tablets, especially controlled release pharmaceutical tablets. The controlled release properties of the tablets formed from granules prepared according to the present invention are unexpectedly better than tablets prepared from granules formed by other known granulation methods.

Controlled release polyacrylic acid granules and a process for preparing the same

The present invention pertains to a method for forming poly-acrylic acid granules and granules formed therefrom wherein the granules are flowable, have an increased bulk density relative to the as polymerized polyacrylic acids, and a low amount of dust which is generally characterized herein as particles which pass through a 325 mesh screen. The granules formed by the method of the present invention can be used to prepare controlled release tablets, especially controlled release pharmaceutical tablets. The controlled release properties of the tablets formed from granules prepared according to the present invention are unexpectedly better than tablets prepared from granules formed by other known granulation methods.

A method for forming polyacrylic acid granules and granules prepared therefrom, wherein the granules are flowable, have comparable swelling characteristics and provide comparable tablet properties to powdered polyacrylic acid, have increased bulk density and contain minimal amounts of very small particles that can cause dusting and static adherence. The granules are used to prepare controlled-release tablets, especially for pharmaceutical purposes. The tablets prepared from granules obtained by the method of present invention have superior controlled release properties.

A polymeric thickener, emulsifier or suspension aid having improved wettability which is an interpolymer of at least one olefinically unsaturated carboxylic acid containing at least one activated carbon-to-carbon olefinic double bond and at least one carboxyl group, in an amount of more than 15% by weight based upon the weight of the interpolymer, and at least one steric stabilizer surfactant having at least one hydrophilic moiety and at least one hydrophobic moiety and a linear block or a random comb configuration, or mixtures thereof, where the interpolymer has admixed therewith a wetting additive such as a low surface tension surfactant, a glycol, a polyhydric alcohol or mixtures thereof, and a process for dispersing the interpolymer by adding a low surface tension surfactant to the water into which the interpolymer is being dispersed.

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Cuyahoga Falls, OH, United States of America

Daniel James Adams