Hughes General Contractors, Inc.

Seacoast Neuroscience, Inc.

Other

Shure Acquisition Holdings, Inc.

Seacoast Neurosciene, Inc.

Daniel J Pratt

Elizabeth Ahra Cho

Martin P Redmon

Mark T Kieras

Michael J Alwicker

Jeff Segota

Keith G Baker

Samuel S Macausland

John Miller

Keith Baker

Method of forming a concrete slab to reduce or eliminate control joints includes preparing a substantially flat base, overlaying one or more barriers on top of the base, placing a concrete mixture on top of the barrier(s) and base to form a concrete slab, and allowing the concrete to cure without forming control joints. The base is prepared with a flatness of about &#xb1;&#xbc; inch over 10 feet. A side edge is prepared along a periphery of the concrete slab by extending a vapor barrier from a bottom surface of the slab up the side edge toward a top surface of the slab and covering the side edge. A plurality of post-tensioning cables are positioned to extend through the slab and configured to compress and assist in controlling accelerated displacement of the concrete slab during curing and shrinkage. The concrete slab is formed of an evenly gradated and low slump concrete having high fiber content, minimized cement content, and maximized size of large aggregate.

Joint-free concrete

The invention provides compositions and methods for treating a subject who has suffered from a central nervous system disorder. More particularly, the invention provides sustained polymeric drug delivery systems having a polymer particle, a therapeutic agent, and a buoyancy agent for direct delivery of therapeutic agents into the central nervous system.

Buoyant polymer particles for delivery of therapeutic agents to the central nervous system

A method for universally distributing a therapeutic agent, in an encapsulated form, to the brain of a subject using intrathecal administration, excluding the lumbar region, is described. Methods for treating stroke and/or Traumatic Brain Injury (TBI) are also described. The methods involve intrathecal administration into the cerebrospinal fluid of a subject, of a therapeutic agent in an encapsulated form. Pharmaceutical compositions intended for the amelioration of stroke and/or Traumatic Brain Injury (TBI) are also described. The pharmaceutical compositions comprise a therapeutic agent encapsulated in a pharmaceutically acceptable polymer, suitable for injection into the cerebrospinal fluid of a subject suffering from stroke and/or Traumatic Brain Injury (TBI).

Methods for universally distributing therapeutic agents to the brain

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Farmington, UT, United States of America

Daniel J Pratt