Centre for Addiction and Mental Health

Daniel J Mueller

James Lowery Kennedy

Clement C Zai

Nabilah I Chowdhury

Vanessa F Gonçalves

Arun K Tiwari

Eva J Brandl

Jennie G Pouget

Vanessa F Goncalves

James L Kennedy

The invention provides methods and compositions for the treatment of a subject having a psychiatric disease or disorder based upon the subject's genotype and/or the number of risk alleles carried by the subject, which risk alleles have been found by the present inventors to predispose a subject to antipsychotic medication induced weight gain (AIWG). The methods of the invention also provide for different treatments, or different treatment regimens, for the subject depending on the subject's risk of AIWG. Related compositions, in the form of kits, systems, and computer-readable media are also provided.

Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain

Provided is a method of predicting a subject's weight response to antipsychotic drug treatment by obtaining a biological sample comprising genomic DNA from the subject and determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject, wherein the presence of said one or more polymorphisms is predictive of the subject's weight change in response to antipsychotic drug treatment. The method also may comprise additional steps including treating the subject. Kits and components thereof are also provided.

Genetic markers for antipsychotic induced weight gain and methods for use thereof

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Toronto, Canada

Daniel J Mueller