The General Hospital Corporation

Daniel J McAuliffe

Apostolos G Doukas

Thomas J Flotte

Nikiforos Kollias

Shun Lee

Therese M Anderson

John A Parrish

Steven L Jacques

Irvin H Blank

A method for delivering compounds through epithelial cell layers using impulse transients is described. The method involves applying a compound to, e.g., the stratum corneum, of a patient and then inducing impulse transients to create transient increases in the permeability of epithelial tissue, thereby facilitating delivery of the compound across the epithelial cell layer.

Compound delivery using impulse transients

A method of increasing delivery of a compound from an exterior region to an interior region of a cell without causing substantial lethality to the cell. The method includes the steps of first providing the compound in the exterior region proximal to a membrane of the cell, and then exposing the membrane to a time-dependent impulse transient characterized by a rise time and a magnitude. In this manner, the exposing step temporarily increases the permeability of the membrane, resulting in an increase in the diffusion of the compound from the exterior region to the interior region thereby enhancing the delivery of the compound without causing substantial lethality to the cell.

Compound delivery using high-pressure impulse transients

A method of treating diseases of cell proliferation in a patient such as neoplasms and rheumatoid arthritis including administering sub-toxic doses of a compound in combination with high pressure impulse transients. Methods are also provided for identifying compounds and impulse transient dosages useful for high pressure impulse transient chemotherapy.

High-pressure impulse transient drug delivery for the treatment of

A method of administering a therapeutic substance to a human patient, the method having the steps of ablating the stratum corneum of a region of the skin of the patient using pulsed laser light of wavelength, pulse length, pulse energy, pulse number, and pulse repetition rate sufficient to ablate the stratum corneum without significantly damaging the underlying epidermis, and applying the therapeutic substance to the region of ablation.

Growing community of inventors

Boxford, MA, United States of America

Daniel J McAuliffe