Leland Stanford Junior University

Applaud Medical, Inc.

Myka Labs, Inc.

Wave 80 Biosciences, Inc.

Daniel J Laser

Juan G Santiago

Thomas W Kenny

Kenneth E Goodson

Chuan-Hua Chen

James C Mikkelsen

Shulin Zeng

Linan Jiang

David E Huber

Jae-Mo Koo

Evelyn Ning-Yi Wang

Lian Zhang

Robert G Miotke

Alice Luong

William Behnke-Parks

Amy Droitcour

Hailemariam Negussie

Robert H Grubbs

John H Jerman

Michael Richard Harrison

Lee L Swanstrom

Radu Raduta

Colin Brahmstedt

Jared Frey

A dual-flange stent can have a therapeutic effect that can bring about a marked increase in patency. The dual flanges of the stent can comprise a first discrete flange component and a second discrete flange component. One or both flange components can include a magnetic element. The stent can further comprise a shaft connecting the flange components. At least one of the flanges can transition between a first configuration and a second configuration, where the first configuration is compact and the second configuration provides a large tissue-compressing surface. In one instance, the transition to the configuration with a large tissue-compressing surface can include filling a balloon with saline or another fluid. The first flange and the second flange may be drawn together to compress interposed tissue of the stricture.

Expanding devices for endoluminal interventions

The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.

Method of treating urolithiasis

The present invention is directed to a novel target detecting device comprising an excitation transducer generating a low frequency pulses of weakly focused ultrasonic energy and a sensing transducer. The present invention also includes a method of aligning a treatment transducer to a target by mapping the target in situ by sending a low frequency ultrasound signal and receiving reflected signals from the target. These inventions provide a simpler way of determining the location of a target and aligning a treatment transducer without the need to generate and interpret an image and then translate the image back onto the target.

System and method for detecting and aligning acoustic beam in situ to a target using wide-beam, low frequency (<1 mhz) ultrasound

Methods of manufacturing microspheres

A system is configured to bring about anastomosis between two lumens in a patient or between two sections of a single lumen in a patient. The anastomosis system includes a first tissue-compressing element, a second tissue-compressing element, and an energy source. The energy source can be a thermal energy source or laser energy source. Tissue is interposed between the elements. Magnetic material incorporated into the tissue-compressing elements facilitates the alignment of the elements as well as compression of the interposed tissue. The energy source can deliver energy to tissue. This delivery of energy can cause local changes to the tissue that can help maintain positional stability of the implants, can bring about immediate patency of the anastomosis and can otherwise facilitate achieving desired outcomes for the patient.

Accelerated patency magnamosis

A system and a method are disclosed for forming an anastomosis between a first layer of tissue and a second layer of tissue of a patient's body. The system includes a first anastomosis device component and a second anastomosis device component configured to interact with the first anastomosis device component. The first anastomosis device component is configured to be delivered to a first lumen inside the patient's body. The second anastomosis device component is configured to be delivered to a second lumen inside the patient's body. The second anastomosis device includes one or more sensors configured to capture sensor data for determining an alignment of the second anastomosis device component relative to the first anastomosis device component, or for characterizing the position or orientation of the second anastomosis device component in three-dimensional space.

Feedback controlled anastomosis devices

Phospholipid compounds and formulations

System and method for detecting and aligning acoustic beam in situ to a target using wide-beam, low frequency (&#x3c;1 MHz) ultrasound

Methods and systems are provided for a microfluidic cartridge including a high performance actuator useful for analyte detection, labeling and analysis. Microfluidic processing systems are to carry out chemical or biochemical reactions, or sequences of reactions, with small volumes (typically between 1 microliter and 10 milliliters) of reactants and products. A microfluidic processing system can comprise a network of tubes interfaced with discrete components such as valves and sensors, or an integrated device made of plastic, glass, metal, or other materials, or a combination of materials, with components such as valves and sensors built into the device and connected by flow passageways formed in the material.

Methods and systems for enhanced microfluidic processing

A microfluidic device includes a three-dimensional slat structure having a plurality of interstices configured to generate a high power, high flow rate of fluids by electroosmotic flow. The microfluidic device includes a housing for holding and moving fluids through the slat structure, and a plurality of electrodes that generate an electric field within the plurality of interstices.

Long-throw microfluidic actuator

Apparatus and methods according to the present invention utilize micropumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These micropumps are fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These micropumps also can allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the spatial and temporal characteristics of the device temperature profiles. Novel enclosed microchannel structures are also described.

Closed-loop microchannel cooling system

An electroosmotic micropump having a plurality of thin, closely-spaced, approximately planar, transversel aligned partitions formed in or on a substrate, among which electroosmotic flow (EOF) is generated. Electrodes are located within enclosed inlet and outlet manifolds on either side of the partition array. Inlet and outlet ports enable fluid to be pumped into and through the micropump and through an external friction load or head. Insulating layer coatings on the formed substrate limit substrate leakage current during pumping operation.

Electroosmotic micropump with planar features

Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles. Novel microchannel structures are also described.

Electroosmotic microchannel cooling system

Growing community of inventors

San Francisco, CA, United States of America

Daniel J Laser