Ortho Pharmaceutical Corporation

University of California

The General Hospital Corporation

Johnson Matthey Inc.

Daniel J Kroon

Gideon Goldstein

George Heavner

Tapan Audhya

Maurizio Zanetti

Edward Golub

Petar Lenert

Gary James Bridger

Alan J Fischman

Robert H Rubin

John D Higgins, Iii

H William Strauss

Scott K Larsen

Claudia K Derian

Howard F Solomon

Pedro E Hernandez

Anthony J Fuccello

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure

Labeled chemotactic peptides to image focal sites of infection or

A method of separating V.sub.H containing immunoglobulins by admixing an immunoglobulin binding peptide is described. The polypeptide of the invention is capable of binding to heavy chain variable regions of antibodies in an antigen independent manner and can separate antigen/antibody complexes.

Immunoglobulin-binding polypeptides

Polypeptides having a segment capable of binding to immunoglobulin heavy chain variable regions (V.sub.H) in an antigen independent manner have been described. These polypeptides can be used to form complexes with V.sub.M containing molecules for diagnostic purposes and to increase the affinity of the antibody for its antigen. Additionally, the polypeptides of the invention can be used to separate V.sub.H containing molecules from solution to form isolated V.sub.H or V.sub.H depleted compositions.

Synthetic peptides which possess the ability to specifically induce the differentiation of precursor B cells into mature B-cells capable of producing antibody.

B cell differentiating peptides and conjugates thereof

B-cell differentiating peptides

Immunoregulating peptides are disclosed which are more potent than thymopentin or splenin and are useful for their effects on the immune system, especially the treatment of thymic deficiencies.

Potent thymopentin analogs

A synthetic peptide which possesses the ability to specifically induce the differentiation of precursor B cells into mature B-cells capable of producing antibody.

Bursopoietin

Peptides which have thymopoeitin-like or splenin-like activity combined with greatly increased resistance to degradation by enzymes. The peptides are useful for treatment of immunoregulatory disorders. Also provided are methods of treating immunoregulatory disorders and compositions used in these methods.

Enzyme-resistant immunomodulatory peptides

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Bridgewater, NJ, United States of America

Daniel J Kroon