Bristol-myers Squibb Compnay

Merck + Co., Inc.

Daniel J Keavy

Michael Frederick Parker

Graham Johnson

Ronald J Mattson

Katherine S Takaki

John D Catt

Joseph P Yevich

Brett T Watson

George N Karageorge

Milind Deshpande

Benito Munoz

Prasad V Chaturvedula

Owen Brendan Wallace

Carl P Bergstrom

David W Smith

Charles P Sloan

James R Epperson

Kumar Srinivasan

Wai Yu Lau

Henry Hui Wang

In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid &#x3b2; protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.

Sulfonamide compounds and uses thereof

Novel derivatives of benzopyran are provided which are useful as melatonergic agents.

Benzopyran derivatives as melatonergic agents

Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.

Benzodioxa alkylene ethers as melatonergic agents

Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH.sub.2).sub.n, wherein n is 1-4;

Polycyclic ethyl alkylamide melatonergic agents

Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.

N-acyl-2-aryl cyclopropylmethylamine derivatives as melatonergics

Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.

Benzofuran and dihydrobenzofuran melatonergic agents

N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics

New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R.sub.1 =C.sub.1-3 alkyl, allyl, C.sub.3-6 cycloalkyl substituted C.sub.1-4 alkyl;

Melatonergic agents

Certain N-acyl-cycloalkylamine derivatives are useful as melatonergic agents.

N-acyl-cycloalkylamine derivatives as melatonergics

Novel 3-alkoxybenzylpiperidines have melatonergic properties. They are believed useful in treating depression, jet-lag, work-shift syndrome, sleep disorders, glaucoma, some disorders associated with reproduction, cancer, immune disorders and neuroendocrine disorders.

Growing community of inventors

Middletown, CT, United States of America

Daniel J Keavy