University of Kansas

Hylapharm, LLC

Other

Daniel J Aires

Shuang Cai

Ti Zhang

Peter S N Rowe

M Laird Forrest

Kenneth Ryan Moulder

Aline Martin

Nicolae Valentin David

Laird Forrest

Jordan Hunt

Peter Kleindl

Ryan Moulder

Ruolin Lu

Qiuhong Yang

Chad E Groer

Chad Groer

Marcus Laird Forrest

Shaofeng Duan

The present technology is directed to TLR7 and TLR8 agonist compounds, compositions, and methods of using the same for the treatment of cancers and as vaccine adjuvants.

Imidazoquinoline compounds and prodrugs thereof

Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

Platinum(IV) conjugates and methods of use

A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. In one aspect, the method can include administering the composition topically so as to administer the polypeptide to the subject. In one aspect, the method can include administering the polypeptide to skin of the subject. In one aspect, the method can include administering the polypeptide to a hair follicle of the subject. In one aspect, the method can include administering the polypeptide to a bald spot of the subject.

Compounds and methods for increasing hair growth

Pick guard

An ergonomic electric guitar includes a neck frets, a plurality of strings, and a body. The body includes a bridge having a nominal string anchor point for the strings, an upper bass bout including a front strap attachment mechanism having a front strap attachment point that is disposed within a predefined region. The body also includes a rear strap attachment mechanism having a rear strap attachment point disposed within a predefined region and a lower bass bout including a generally wedge-shaped region disposed between a medial portion of a front face of the lower bass bout and extending to a peripheral side wall of the lower bass bout and the lower bass bout extends substantially beyond a first arc and is substantially within a second arc. The strings extend in a first direction from the bridge to a distal portion of the neck.

Ergonomic guitar

A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820.

Drug and imaging agent delivery compositions and methods

Growing community of inventors

Prairie Village, KS, United States of America

Daniel J Aires