Cerebral Therapeutics, Inc.

University of Colorado

Biogen Ma Inc.

Daniel J Abrams

Lisa Lynn Shafer

Michael Canney

Thomas J Anchordoquy

Thomas Joseph Anchordoguy

Michael S Canney

Matias Maturana

An intraventricular access device for infusion of drugs and aspiration of cerebrospinal fluid (CSF). The device includes a container configured to couple to an aspiration lumen through which CSF may be aspirated or through which drugs may be injected. The container is further configured to couple to an infusion lumen and to a drug pump via a catheter. The container thus forms a pathway connectable to the catheter through which a drug from the drug pump may be infused to flow through the infusion lumen into the CSF. The container includes a volume that is accessible by an aspiration needle, for example through a material that reseals upon extraction of the needle. Moreover, the container is configured to prevent cross contamination between a first fluid in the aspiration lumen and a second fluid in the infusion lumen.

Infusing drug solution directly into brain fluid

An implantable medical device for delivering therapeutic fluid to, and withdrawing cerebrospinal fluid (CSF) from, a CSF-containing space, includes a first inlet configured to be accessed by a needle of an aspiration device; a first outlet; a first fluid pathway extending from the first inlet to the first outlet; a second inlet; a second outlet; and a second fluid pathway extending from the second inlet to the second outlet. The first fluid pathway is free of a filter configured to prevent passage of a microbe.

Medical device having non-filtered CSF withdrawal pathway

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. In some embodiments, the container may include a barrier positioned between a proximal opening of the aspiration lumen and at least a portion of the infusion lumen adjacent to and/or associated with the container. The barrier may inhibit penetration of a surgical instrument.

Implantable intraventricular sampling and infusion access device

Highly concentrated solutions are disclosed along with methods of inhibiting and/or ameliorating functional neurological disorders of the brain. The method may include administering directly to a brain of a subject a medicament multiple times over a time period of at least two days. The medicament may include a half-life of less than 2 hour in the cerebrospinal fluid. The method may include inhibiting and/or ameliorating a functional neurological disorder of the brain using the medicant.

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Aurora, CO, United States of America

Daniel J Abrams