Roche Diagnostics Operations, Inc.

Daniel Intelmann

Anton Hilger

Shirin Shahriari

Nadja Arens

Andrea Geistanger

Albert Geiger

Kirill Tarasov

Ruediger Laubender

Julian Michely

Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.

Calibration of mass spectrometry systems

A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function ffor a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fdescribes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fis a parametrized function f(concentration), with p=(p,p, . . . p) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)},{circumflex over (p)}, . . . {circumflex over (p)}) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

Method for calibrating at least one mass spectrometry device

A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sis acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.

Method for calibrating at least one analytic device with multiple repeated hardware components

A method for monitoring an analyzer including a liquid chromatography device (LC) having at least two liquid chromatography (LC) streams, the method including continuously monitoring one or more parameters in measurement data of samples in each of the at least two LC streams, the one or more parameters being independent of an analyte concentration of the respective sample, determining if the one or more monitored parameters show an expected behavior and triggering a response upon detection that the one or more monitored parameters deviate from the expected behavior.

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Schaftlach, Germany

Daniel Intelmann