Genetronics, Inc.

Inovio Pharmaceuticals, Inc.

Daniel Holt

Gunter A Hofmann

Gurvinder S Nanda

Edward Nolan

Steve Dimmer

Steven Dimmer

Gurvinder Nanda

Edward M Nolan

A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.

Method and apparatus for reducing electroporation-mediated muscle reaction and pain response

Growing community of inventors

Mira Mesa, CA, United States of America

Daniel Holt