Saint Louis University

Epivax, Inc.

Daniel Hoft

Annie De Groot

Chris Eickhoff

Christopher S Eickhoff

The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infection also are described.

Peptides for inducing heterosubtypic influenza T cell responses

The present disclosure relates to vaccine formulations and their use in treating and preventing Chagas Disease.

Peptides for inducing Chagas disease responses

The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infaction also are described.

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St. Louis, MO, United States of America

Daniel Hoft