Ut-battelle, Inc.

Abt Molecular Imaging, Inc.

Daniel Hillesheim

John T Simpson

Mariappan Parans Paranthaman

Tolga Aytug

Beth Louise Armstrong

Aaron McFarland

Atilio Anzellotti

Clive Brown-Proctor

Mark Haig Khachaturian

Neil E Trammell

Andrew Land

Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall.

Dose synthesis card for use with automated biomarker production system

An optically transparent, hydrophobic coating, exhibiting an average contact angle of at least 100 degrees with a drop of water. The coating can be produced using low-cost, environmentally friendly components. Methods of preparing and using the optically transparent, hydrophobic coating.

Optically transparent, superhydrophobic, biocompatible thin film coatings and methods for producing same

Growing community of inventors

Knoxville, TN, United States of America

Daniel Hillesheim