University of California

University of Florida Research Foundation Inc

Daniel Hensley

Steven M Conolly

Bo Zheng

Patrick W Goodwill

Zhi Wei Tay

Carlos Rinaldi

Rohan Deepak Dhavalikar

Shehaab Savliwala

Prashant Chandrasekharan

A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion.

Pulsed magnetic particle imaging systems and methods

A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles. The magnetic particle imaging system further includes signal processor in communication with the detection system, configured to receive and process the detected signal to remove a coercivity shift due to the coercivity of the strongly-interacting magnetic particles, and convert the processed detection signal into an image of the strongly-interacting magnetic particles.

Strongly-interacting magnetic particle imaging

Growing community of inventors

Berkeley, CA, United States of America

Daniel Hensley