Inscripta, Inc.

Daniel Held

Richard Fox

Eric Abbate

Michael Clay

Katherine Krouse

Nandini Krishnamurthy

Krishna Yerramsetty

Andrew Garst

Tian Tian

The present disclosure relates to various different types of mutations in the thrA gene inleading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Rationally-designed mutations to the thrA gene for enhanced lysine production in

The present disclosure relates to compositions, methods, modules and automated integrated instrumentation for multiplex delivery of 'landing pad' edits into the genomes of a population of live cells. The landing pads then may be leveraged to insert very large DNA sequences into the genomes of the population of live cells.

CRISPR editing to embed nucleic acid landing pads into genomes of live cells

The present disclosure provides shuttle vectors for editing exogenous polynucleotides in heterologous live cells, as well as automated methods, modules, and multi-module cell editing instruments and systems for performing the editing methods.

Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells

The present disclosure provides compositions and methods to increase the percentage of edited cells in a cell population when employing nucleic-acid guided editing, as well as automated multi-module instruments for performing these methods. Specifically, the disclosure relates to methods, compositions, modules and automated multi-module cell processing instruments that increase the efficiency of nucleic acid-guided editing in a cell population using a nucleic acid nuclease (i.e., an RNA-guided nuclease or 'RGN')/single-strand binding protein ('SSB') fusion system. The system leverages a single-strand binding protein (SSP) and single-strand DNA annealing protein (&#x201c;SSAP&#x201d;) interactions to drive enhanced recruitment.

Affinity tag for recombination protein recruitment

The present disclosure relates to various different types of variants incoding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Growing community of inventors

Boulder, CO, United States of America

Daniel Held