South Dakota Board of Regents

Rochester Institute of Technology

Daniel Heglund

Scott A Williams

Zhengtao Zhu

Andrew Olson

Joseph A Marshall

Yichun Ding

Neal Hodges

Hunter Moyer

The present disclosure relates to compositions and systems for improving tissue perfusion such that blood flow is increased, improving tissue healing time and reducing or eliminating tissue necrosis. In a preferred embodiment, the compositions comprise a phosphodiesterase inhibitor, a calcium channel blocker, a nitric oxide producer, and an α-adrenergic antagonist. Methods of making the compositions and using the compositions are also disclosed.

Vasoactive topical compound to affect tissue blood flow, reduce tissue necrosis and promote healing

This disclosure is related to a class of metal-ion induced hydrophobic polymers and method of producing such class of compounds by a one-step solution immersion process. Specifically, a metal-ion Induced hydrophobic polymer or melamine sponge (MII-HMS) is disclosed. Such polymer or sponge is demonstrated to be highly hydrophobic and oleophilic and exhibits excellent oil absorption capabilities, being able to absorb a wide range of oils and organic solvents up to 71 to 157 times of its own weight.

Highly hydrophobic and oleophilic melamine resin via metal-ion induced wettability transition, application, and preparation thereof

The present invention relates to methods of testing medications to evaluate authenticity and identify counterfeits. The testing methods employ a reactive system comprising a solvent and an acid. Optionally, the reactive system can also comprise an organometallic agent. The testing methods can provide rapid results verifying the authenticity of an antimalarial medication. Further the test method can provide clear results that can be implemented and interpreted without special training, anywhere in the world. The test methods can offer quantitative and qualitative results. The test methods are based on reactions that yield different colors where the color can indicate the presence of an active ingredient, and the intensity of the color can indicate the concentration of the active ingredient.

Chemical assay to verify the quantity and quality of sesquiterpene lactone derivatives

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Rapid City, SD, United States of America

Daniel Heglund