University of Michigan

Daniel H Teitelbaum

Diann Brei

Jonathan E Luntz

Brent Allen Utter

Farokh R Demehri

Ariel Uzziah Spencer

Jennifer Freeman

Scott D Larsen

Hollis Showalter

Hiroyuki Koga

Hua Yang

Peter Lucas

Joseph T Belter

Yumi Fukatsu

Jennifer L Vermeesch

Alexander D Farr

Makram P Debbas

Barbara E Wildhaber

Diann Erbschloe Brei

An attachment system for selectively attaching to an interior surface of a hollow member, which includes an expanding device selectively enlargeable from a first size position to an enlarged second size position, a friction enhancement disposed about the expanding device that is engageable with the interior surface of the hollow member when the expanding device is in the enlarged position, and a fenestrated decoupling system extending between at least a portion of the friction enhancement of the expanding device and the interior surface of the hollow member. The fenestrated decoupling system generally prevents contact of the friction enhancement with the interior surface of the hollow member when the expanding device is in the first size position and permits contact of the friction enhancement with the interior surface of the hollow member when the expanding device is in the enlarged position.

Fenestrated decoupling system for internal selective attachment to soft tissue organs

An indwelling device for insertion in a biological tubular structure comprising an elongated device having a body and opposing ends. The body has a bending stiffness transverse to a longitudinal axis that is greater than a stiffness of the biological tubular structure. An atraumatic tip member, having a proximal end and a distal end, extends from the end of the elongated device. The proximal end has a first bending stiffness transverse to a longitudinal axis and the distal end has a second bending stiffness transverse to the longitudinal axis, wherein the second bending stiffness being less than the first bending stiffness.

Atraumatic tip geometry for indwelling devices

The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.

Compositions and methods for treating inflammatory conditions of the bowel

A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.

Mechanical extension implants for short bowel syndrome

The present invention provides compositions and methods for treating inflammatory bowel disease. In particular, the present invention provides methods of therapeutically treating symptoms of inflammatory bowel disease using compositions comprising an angiotensin converting enzyme (ACE) inhibitor and polyethylene glycol.

Compositions and methods for treatment of inflammatory bowel disease

Growing community of inventors

Ann Arbor, MI, United States of America

Daniel H Teitelbaum