Sibia Neurosciences, Inc.

Merck + Co., Inc.

The Salk Institute Biotechnology/industrial Assoc, Inc.

Daniel H Feldman

Michael Miller Harpold

Steven B Ellis

Mark E Williams

Robert Brenner

Ann F McCue

Alison Gillespie

Isolated DNA encoding each of human calcium channel &#x3b1;, &#x3b1;, &#x3b2;- and &#x3b3;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Human calcium channel compositions and methods

Isolated DNA encoding each of human calcium channel &agr; -, &agr; -, &bgr;- and &ggr;-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.

Assays of cells expressing human calcium channels containing

Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.-and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1,

Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Growing community of inventors

Gainesville, FL, United States of America

Daniel H Feldman