L'oreal

Rhone-poulenc Sante

Centre National De La Recherche Scientifique

Daniel Guenard

Pierre Potier

Francoise Gueritte-Voegelein

Thierry Sevenet

Ming Li

Eric Pilleux

Michel Colin

Hubert Schaller

Hamid Abdul Hadi

Claude Thal

Jean-Noel Denis

Andrew E Greene

Jean-Pierre Cosson

Olivier Boye

A depigmenting cosmetic or dermatological composition containing, as active ingredient, at least one di- or tri-caffeoylquinic acid corresponding to general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent a hydrogen atom or the CAF radical corresponding to the formula: ##STR2## provided that at least two, and at most three, of the R.sub.1, R.sub.2, R.sub.3, and R.sub.4 radicals represent the CAF radical, but excluding R.sub.1 and R.sub.2 as representing the CAF radical and R.sub.2 and R.sub.3 as representing a hydrogen atom, or a mixture of said caffeoylquinic acids.

Depigmenting cosmetic and/or dermatological composition containing a di-

A depigmenting cosmetic or dermatological composition containing, as active ingredient, at least one di- or tri-caffeoylquinic acid corresponding to general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent a hydrogen atom or the CAF radical corresponding to the formula: ##STR2## provided that at least two, and at most three, of the R.sub.1, R.sub.2, R.sub.3, and R.sub.4 radicals represent the CAF radical, but excluding R.sub.1 and R.sub.4 as representing the CAF radical and R.sub.2 and R.sub.3 as representing a hydrogen atom, or a mixture of said caffeoylquinic acids.

A cosmetic or dermatological composition contains as an active ingredient at least one arbutoside derivative with the following general formula: ##STR1## wherein: R represents an unsaturated aliphatic or aromatic hydroxylated residue having 4 to 16 carbon atoms, and R' represents a hydrogen atom or the ##STR2## radical. Ar represents a phenyl radical that may be substituted by one or more hydroxyl groups. Applications of the composition include the bleaching of skin and the treatment of pigmented spots.

Depigmenting cosmetic or dermatological composition containing

Phenylpyrrolic compounds used as drugs, their preparation and application

Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-deacetylbaccatine III of general formula (III), R.sub.1, R.sub.2 and R.sub.3 denoting hydroxy-protecting groups, followed by the replacement of the protecting groups by hydrogen. ##STR1##

Process for preparing derivatives of baccatine III and of 10-deacetyl

Process for preparing taxol by the condensation of a (2R, 3S) acid of general formula (I) with a taxan derivative of general formula (II), followed by the removal of the groups R.sub.2 and R.sub.3 protecting the hydroxy groups. ##STR1##

Process for preparing taxol

Taxol and 10-deacetyltaxol are prepared from a compound of formula: ##STR1## in which R' represents acetyl or 2,2,2-trichloroethoxycarbonyl radical, by removal of the t-butoxycarbonyl radical, benzoylation of the amine product obtained, and removal of the 2,2,2-trichloroethoxycarbonyl group(s).

Process for the preparation of taxol and 10-deacetyltaxol

Taxol derivatives of formula ##STR1## in which R represents hydrogen or acetyl, one of R.sub.1 or R.sub.2 represents hydroxy and the other represents tert-butoxycarbonylamino and their isomers are useful antitumor agents.

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Montrouge, France

Daniel Guenard