Duke University

Washington University

Daniel George

Jennifer Freedman

Bruce A Sullenger

Steven R Patierno

Brendon Patierno

Bonnie Lacroix

Timothy Robinson

Katherine J Franz

Bi-Dar Wang

Norman Lee

Steven Patierno

Yanru Wang

Hongliang Liu

Qingyi Wei

Mark Sleeper

Subha Bakthavatsalam

Tian Zhang

The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.

Splice-switching oligonucleotides and methods of use

The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR expression and methods of using these splice-switching oligonucleotides to treat cancer, specifically castrate resistant prostate cancer.

The present disclosure provides prochelators as targeted prodrugs for cancer, such as prostate cancer, and methods of making and using the same.

Prochelators as targeted prodrugs for prostate cancer and methods of making and using same

The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.

Biomarkers for the identification of prostate cancer and methods of use

Growing community of inventors

Durham, NC, United States of America

Daniel George