Genentech, Inc.

Daniel G M Shore

Mark Edward Zak

Naomi S Rajapaksa

Yun-Xing Cheng

Marian C Bryan

Jessica Grandner

F Anthony Romero

Compounds of formula (I) wherein R, R, R, R, Rand Rare as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Substituted pyrazolo[1,5-a]pyrimidines as inhibitors of JAK kinases

Compounds of formula (I) wherein R, R, R, R, Rand Rare as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Pyrazolopyrimidine inhibitors of JAK kinases and uses thereof

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Redwood City, CA, United States of America

Daniel G M Shore