Angiotech Biocoatings, Inc.

Daniel G Hullihen

Richard J Whitbourne

Mildred Calistri-Yeh

Scott F Rosebrough

Alexandra M Chamberlain

Michael R Violante

Xianping Zhang

Frank Guo-Bin Wang

This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.

Medicated stent having multi-layer polymer coating

Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.

Targeted therapeutic agent release devices and methods of making and using the same

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Caledonia, NY, United States of America

Daniel G Hullihen