Nutcracker Therapeutics, Inc.

Senti Biosciences, Inc.

Daniel Frimannsson

Timothy Kuan-Ta Lu

Philip Janmin Lee

Russell Morrison Gordley

Ole Haabeth

Brian Scott Garrison

Jack Tzu-Chiao Lin

Alba Gonzalez-Junca

Don-Hong Wang

Samuel Deutsch

Nicole Fay

Colin James McKinlay

Colin McKINLAY

Provided herein are examples of mRNA treatment nanoparticles and methods of using them to treat a patient. An mRNA treatment nanoparticle may include one or more mRNAs encoding a tumor-specific antigen and an immunomodulatory agent; and a delivery vehicle molecule encapsulating the one or more mRNAs.

mRNA treatment nanoparticles

MRNA treatment nanoparticles

Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.

Combinatorial cancer immunotherapy

Growing community of inventors

Alameda, CA, United States of America

Daniel Frimannsson