Sanofi

Sanofi-aventis

Elf Sanofi

Sanofi Sa

Parcor

Pacor

Daniel Frehel

Jean-Pierre Maffrand

Alain Badorc

Pierre Despeyroux

Danielle Gully

Paul De Cointet

Eric Vallee

Jean-Pierre Bras

Robert Boigegrain

Bruno Schoentjes

Viviane Van Dorsselaer

Jean-Marc Herbert

Andre Bernat

Daniele Anne Gully

Gerard Valette

Jean-Charles Molimard

Dominique Olliero

Claudine Serradeil-Legal

Roger Brodin

Gerard Ferrand

Pierre Savi

Marie-Francoise Bordes

Antonina Giudice

Rebecca Pruss

Eric Bignon

Andr E Bernat

Denis Delebassee

Denis Delabassee

Denis Delebass Ee

Chantal Guenet

Daniel Ducros

Corinne Heckel

Jean Courregelongue

Pierre Despey-Roux

Ghislain Defreyn

Gilles Kieffer

The present invention discloses and claims therapeutic uses of a compound corresponding to the general formula (I): Wherein, X, R, R, R, R, R, R, Rand n are as described herein.

Therapeutic use of acylaminothiazole derivatives

Compound corresponding to the general formula (I): in which, where Rrepresents a hydrogen atom or a Calkyl; n represents an integer ranging from 0 to 3; and Rrepresents, independently of each other when n=2 or 3, a hydrogen or halogen atom, a hydroxyl, Calkyl, Calkoxy, Cfluoroalkyl or Cfluoroalkoxy group;in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. therapeutic application.

Acylaminothiazole derivatives, their preparation and their therapeutic use

The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; Rrepresents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C-Calkyl, a C-Calkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; Rrepresents a C-Calkyl group optionally substituted, a C-Ccycloalkyl, piperidinyl or phenyl group, the C-Ccycloalkyl, piperidinyl or phenyl groups being optionally substituted; Rrepresents a hydrogen atom or a C-Calkyl group optionally substituted; Rrepresents a hydrogen atom or a C-C4 alkyl group; and Rand Rrepresent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C-Calkyl group, or Rand Rform together an oxo group; Rrepresents a hydrogen atom, a halogen atom, a C-Calkyl, a C-Calkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy 

Acylaminothiazole derivatives, their preparation and therapeutic use

The invention relates to the compounds of formula (I) ##STR1## in which R.sub.I, R.sub.II, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are as defined in claim 1.

Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one

The present invention relates to compounds of formula: ##STR1## which are agonists of cholecystokinin receptors and pharmaceutical compositions containing them.

Glycinamide derivatives, processes for their preparation and medicines

Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one

The invention relates to the use of a compound of formula: ##STR1## in which Y represents a 3-quinolyl group or a 2-indolyl group of formula: ##STR2## in which: X is chosen from 4-chloro-2,6-dimethoxyphenyl, 2,6-dimethoxy-4-methylphenyl, 2,4,5-trimethoxyphenyl, 4-methyl-2,3,6-trimethoxyphenyl, 2,6-dimethoxy-4-ethylphenyl, 2,4,6-trimethoxy-5-chlorophenyl, 2,4,6-trimethoxy-3-pyridyl, 2,4-dimethoxy-6-methyl-3-pyridyl, 6-chloro-2,4-dimethoxy-5-pyrimidinyl, 2,4,6-trimethoxy-5-pyrimidinyl, 5-chloro-2,4-dimethoxyphenyl, 5-chloro-2-methoxy-4-methylphenyl, 2,5-dimethoxy-4-methylphenyl, 4-trifluoromethyl-2,6-dimethoxyphenyl, 2,4-dimethoxy-5-methylphenyl, 5-ethyl-2,4-dimethoxyphenyl and 2,4-dimethoxyphenyl groups; Z represents H, a C.sub.1 -C.sub.4 -alkyl or a benzyl; for combating complaints whose treatment necessitates a stimulation of the cholecystokinin receptors by a total or partial agonist effect.

Polysubstituted 2-amino-thiazole derivatives

The invention relates to a new method for the secondary prevention of ischemic events comprising administering to a man in need thereof a therapeutically effective amount of a compound selected from clopidogrel and its pharmaceutically acceptable acid addition salts in association with a pharmaceutically acceptable carrier.

Method for the secondary prevention of ischemic events

The invention relates to thiadiazole derivatives corresponding to the general formula ##STR1## in which Ar represents a nitrogen-containing aromatic heterocycle, in particular indolyl which is substituted or unsubstituted on the nitrogen atom with CO--(C.sub.1 -C.sub.4)alkyl; with (CH.sub.2).sub.n COR in which n represents 1 or 2 and R represents OR.sub.1 or NR.sub.1 R.sub.2 with R.sub.1 and R.sub.2, which may be identical or different, representing H or (C.sub.1 -C.sub.4)alkyl; with (C.sub.1 -C.sub.4) hydroxyalkyl; with (C.sub.2 -C.sub.6) alkoxyalkyl; tetrahydropyranyl; or with a --(CH.sub.2).sub.3 -- chain, the last carbon of which is attached to the phenyl ring of the indole to form a 6-membered ring;

5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical

The compounds of the invention having the formula: ##STR1## in which: A, which is a ring condensed with cyclopentane, represents a substituted or unsubstituted thiophene ring, Q represents an alkylene chain, R.sub.1 and R.sub.2 each represent H or an alkyl, or they form, with the nitrogen atom to which they are linked, a saturated nitrogenous heterocyclic ring containing 5 to 7 atoms, R.sub.3 and R.sub.4 each represent H, alkyl, cycloalkyl, trifluoromethyl or an optionally substituted phenyl, thienyl or furyl group or R.sub.3 and R.sub.4 together form a (C.sub.5 -C.sub.8) cycloalkyl, as well as their addition salts with an acid and their quaternary ammonium derivatives. They can be used as medicines.

Ethers of thienocyclopentanone oximes, their preparation and

The invention relates to compounds of formula ##STR1## in which R.sub.1 is selected from the groups R.sub.3 and OR.sub.3, R is selected from H and a group CHR.sub.2 R', in which R.sub.2 is selected from H, alkyl, carboxy and carboxamido and R', is H, alkyl or phenyl, Z represents S or O; and m and n, which may be identical or different, equal 1 or 2, and their N-oxides, salts and quaternary ammonium derivatives. The invention also relates to the process for preparing these compounds, as well as to pharmaceutical compositions containing them.

Derivatives of 2-hydroxythiophene and -furan fused with a

Compounds of formula ##STR1## in which R.sub.1 represents H, an alkyl or a substituted alkyl, R.sub.2 represents H or alkyl and R.sub.3 represents an optionally substituted cycloalkyl or an optionally substituted aromatic group, which can be a phenyl or a heterocyclic group comprising one or more hetero-atoms chosen from O, S and N, or R.sub.2 and R.sub.3 considered together represent the group ##STR2## which is optionally substituted on the phenyl ring, and Z represents a heterocycle comprising one or more heteroatoms chosen from O, S and N, fused with an aromatic ring which can comprise a hetero-atom and can be substituted, the said heterocycle being optionally substituted on N, when it comprises such an atom, by an alkyl or a substituted alkyl group, and the salts of these compounds with acids or bases.

Heterocyclic substituted acylaminothiazoles, their preparation and

N.alpha.-substituted derivatives of N.alpha.-arylsulphonylaminoacyl p-amidinophenylalaninamides, their preparation, their use as medicaments and intermediates for their synthesis.

Derivatives of the N

The present invention relates to the dextro-rotatory enantiomer of Formula ##STR1## and its pharmaceutically acceptable salts with platelet aggregation inhibiting activity. The invention also relates to a process for the preparation of this compound starting from the racemate and the pharmaceutical compositions containing it.

Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro (3,2-c)

The present invention is concerned with compounds with the formula: ##STR1## in which: R.sub.1 represents a lower alkyl, a lower hydroxy alkyl or a benzyl group, a phenyl group or a 4-hydroxy phenyl group:

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Toulouse, France

Daniel Frehel